1Ahmed M. Amshawee, 2Maryam A. Hussain, 3Seenaa Taqi Mansour al muhtaser, 4Ali A. Al- faham
1Department of Radiology, Hilla University College, Babylon, Iraq,
2Department of Radiology, Hilla University College, Babylon, Iraq,
3Faculty of Pharmacy, University of Kufa, Iraq,
4Faculty of Nursing, University of Kufa, Iraq,
ABSTRACT:
The deoxyribonucleic acid (DNA) carries hereditary codes which is translated by the cells to synthesize the ribonucleic acid (RNA) and polypeptides which can generate and perform vital function. The double helix structure is the most studied model of the DNA that was proposed by Watson and Crick. The capability of DNA to work as a genetic material can be stored and conducted during cell division to permit this information to be doubled and transmitted to the incoming generation. Any damage in the structure of DNA is an essential direct cause for the progression of cancer and other disorders. The factors for DNA damage can be classified as exogenous and endogenous factors. In this review article, we highlight the evidence-supported information about the structure, functions and clinical significance of DNA.
REFERENCES :
1) Aitken, R. J., De Iuliis, G. N., & McLachlan, R. I. (2009). Biological and clinical significance of DNA damage in the male germ line. International journal of andrology, 32(1), 46–56. https://doi.org/10.1111/j.1365-2605.2008.00943.x
2) Case, R., Schollmeyer, H., Kohl, P., Sirota, E. B., Pynn, R., Ewert, K. E., Safinya, C. R., & Li, Y. (2017). Hydration forces between aligned DNA helices undergoing B to A conformational change: In-situ X-ray fiber diffraction studies in a humidity and temperature controlled environment. Journal of structural biology, 200(3), 283–292.
https://doi.org/10.1016/j.jsb.2017.07.003
3) Ghannam JY, Wang J, Jan A. Biochemistry, DNA Structure. [Updated 2023 Jun 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538241/
4) Hakem R. (2008). DNA-damage repair; the good, the bad, and the ugly. The EMBO journal, 27(4), 589–605. https://doi.org/10.1038/emboj.2008.15
5) Heinemann, U. and Roske, Y. (2020) Symmetry in Nucleic-Acid Double Helices. Symmetry, 12, 737. https://doi.org/10.3390/sym12050737
6) Lewis T, Dimri M. Biochemistry, DNA Repair. [Updated 2023 Jul 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560563/
7) Minchin, S., & Lodge, J. (2019). Understanding biochemistry: structure and function of nucleic acids. Essays in biochemistry, 63(4), 433–456.
https://doi.org/10.1042/EBC20180038
8) Pallan, P. S., Lubini, P., Bolli, M., & Egli, M. (2007). Backbone-base inclination as a fundamental determinant of nucleic acid self- and cross-pairing. Nucleic acids research, 35(19), 6611–6624. https://doi.org/10.1093/nar/gkm612
9) Saenger W. (1984) Principles of Nucleic Acid Structure. New York, NY: Springer Verlag Inc.
10) Travers, A., & Muskhelishvili, G. (2015). DNA structure and function. The FEBS journal, 282(12), 2279–2295. https://doi.org/10.1111/febs.13307
11) Trenner, A., & Sartori, A. A. (2019). Harnessing DNA Double-Strand Break Repair for Cancer Treatment. Frontiers in oncology, 9, 1388.
https://doi.org/10.3389/fonc.2019.01388
12) Watson, J. D., & Crick, F. H. (1953). Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature, 171(4356), 737–738. https://doi.org/10.1038/171737a0
13) Zhou, J. C., & Costa, A. (2014). Preparing to unwind. eLife, 3, e02618.
https://doi.org/10.7554/eLife.02618.