ABSTRACT:

Pancreatic cancer is one of the most fatal neoplasias worldwide due to diagnosis at a late stage and poor rates of survival. A highly aggressive neoplasm induces profound histopathological changes and complexity in the microenvironment of the tumor. This review synthesizes recent research findings on the histopathological changes associated with pancreatic cancer, highlights knowledge gaps, and suggests future directions for research. Pancreatic ductal adenocarcinoma is an extremely malignant form of cancer characterized by increased incidence rates and very low rates of survival. Increasing attention to aspects related to risk factors, diagnostics, treatment, and outcomes is becoming mandatory. The present review synthesizes the existing research findings on the etiology of pancreatic cancer, focusing on the main elevated risk factors and genetic sources that explain the histopathological shifts produced during all stages of the illness.

KEYWORDS :

Pathophysiology, Etiology, Pancreatic Cancer, PDAC

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