ABSTRACT:

Interleukin-3 (IL-3) is a cytokine of many activities, centrally important for hematopoiesis and regulation of immune responses. It is produced by activated T cells and mast cells with a large influence on blood cell lineage proliferation and differentiation. Given the biochemistry of IL-3, elucidating its role in health and disease—especially immune responses and pathological conditions—is a high priority. Interleukin-3 is a cytokine profoundly important in the regulation of hematopoiesis and immune responses. The ability of this factor to modulate a wide variety of cellular responses serves to underscore its central involvement in almost all physiological as well as pathological processes. In the present article, the authors summarize recent knowledge on the mechanisms by which IL-3 exerts biological effects, with special emphasis placed on receptor signaling, downstream pathways, and functional responses.

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