Thyroid Metastasis from A Plantar Melanoma: A Rare Case Report and Literature Review

¹NAANANI Othmane, ²CHACHA Hassane, ³A. Rhnia, ⁴M. Lahjaouj, ⁵M. Loudghiri, ⁶W. Bijou, ⁷Y. OUKESSOU, ⁸S.Rouadi, ⁹R.L. ABADA, ¹⁰M. ROUBAL, ¹¹M. MAHTAR

^{1,2,3,4,5,6,7,8,9,10,11}ENT and Cervicofacial Surgery Department, CHU Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanc

DOI: 10.58806/ijhmr.2025.v4i7n02

ABSTRACT

Thyroid metastases are rare in clinical practice. We report the case of a 75-year-old woman with a history of surgically treated plantar malignant melanoma, in whom an isolated thyroid nodule was incidentally discovered during oncologic follow-up. Clinical examination revealed no compressive symptoms or signs of thyroid dysfunction. Cervical ultrasound, followed by ultrasound-guided fine-needle aspiration, showed atypical cells highly suggestive of a melanocytic origin, which was confirmed by immunohistochemistry (positive for HMB-45, S-100, and Melan- A). A total thyroidectomy was performed, and histological analysis confirmed a solitary thyroid metastasis from malignant melanoma. Thyroid function was preserved. This case highlights the importance of considering metastatic disease in the differential diagnosis of thyroid nodules in patients with a history of malignancy, even in the absence of suggestive clinical signs. Thyroidectomy allowed both definitive diagnosis and prevention of potential compressive complications.

KEYWORDS

thyroid metastasis, acral melanoma, fine-needle aspiration, immunohistochemistry

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[cité 17 juin 2025];12. Disponible sur:

https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.93 9965/full

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