ABSTRACT:
The incidence of cancer has dramatically increased around the world. Among the different types, glioma (brain cancer) represents the majority of diagnosed brain tumors and is known to be a rapidly developing tumor with a high mortality rate.
Therapies with viscum album have performed well in cancer treatments and have been the subject of many studies. This work evaluated the in vitro action of homeopathic medicines prepared with viscum album against glioma cells (KNS-42) and was possible to prove the cytotoxic activity of viscum album at D3, D6, D9, D12, and D30 potencies. This result broadens opportunities for homeopathy in cancer treatment as the primary therapy or as a complementary treatment.
KEYWORDS:
Cancer, Viscum Album, Gliome, Homeopathy
REFERENCES :
1) Bonamin, L. V., de Carvalho, A. C., & Waisse, S. (2017). Viscum album (L.) in experimental animal tumors: A meta-
analysis. Experimental and Therapeutic Medicine, 13(6), 2723–2740. https://doi.org/10.3892/etm.2017.4372
2) Braedel-Ruoff, S. (2010). Immunomodulatory Effects of Viscum album Extracts on Natural Killer Cells: Review of
Clinical Trials. Forschende Komplementärmedizin / Research in Complementary Medicine, 17(2), 63–73.
https://doi.org/10.1159/000288702
3) Da Silva Facina, A., Facina, G., Guerreiro da Silva, I. D. C., Aparecida Gonçalves, G., Augusto de Almeida, F., Aparecida
Alves Corrêa de Noronha, S., Marcos Ribeiro de Noronha, S., & Uchiyama Nakamura, M. (2014). Viscum Album
Modulates Apoptotic Related Genes in Melanoma Tumor of Mice. American Journal of Molecular Biology, 04(02), 49–
58. https://doi.org/10.4236/ajmb.2014.42007
4) Grech, N., Dalli, T., Mizzi, S., Meilak, L., Calleja, N., & Zrinzo, A. (2020). Rising Incidence of Glioblastoma Multiforme
in a Well-Defined Population. Cureus. https://doi.org/10.7759/cureus.8195
5) Kim, J. D., Choi, J. W., Park, H. O., Lee, C. E., Jang, I. S., Choi, J. Y., Kang, D. H., Jung, J. J., Yang, J. H., Moon, S. H.,
Byun, J. H., Kim, S. H., & Kim, J. W. (2020). Chemical pleurodesis with Viscum album L. extract for secondary
spontaneous pneumothorax in elderly patients. Journal of Thoracic Disease, 12(10), 5440–5445.
https://doi.org/10.21037/jtd-20-708
6) Menke, K., Schwermer, M., Eisenbraun, J., Schramm, A., & Zuzak, T. J. (2021). Anticancer Effects of Viscum album
Fraxini Extract on Medulloblastoma Cells in vitro. Complementary Medicine Research, 28(1), 15–22.
https://doi.org/10.1159/000507318
7) Nazaruk, J., & Orlikowski, P. (2016). Phytochemical profile and therapeutic potential of Viscum album L. Natural Product
Research, 30(4), 373–385. https://doi.org/10.1080/14786419.2015.1022776
8) Park, Y. J., Mok, S. K., Kim, J. Y., Yun, S. S., & Park, S. C. (2021). Retroperitoneal Viscum album extract instillation in
patients with a large amount of drainage after kidney transplantation. Annals of Surgical Treatment and Research, 101(6),
368. https://doi.org/10.4174/astr.2021.101.6.368
9) Steinborn, C., Klemd, A. M., Sanchez-Campillo, A.-S., Rieger, S., Scheffen, M., Sauer, B., Garcia-Käufer, M., Urech, K.,
Follo, M., Ücker, A., Kienle, G. S., Huber, R., & Gründemann, C. (2017). Viscum album neutralizes tumor-induced
immunosuppression in a human in vitro cell model. PLOS ONE, 12(7), e0181553.
https://doi.org/10.1371/journal.pone.0181553
10) Valle, A. C. V., Aguiar, L. R., Brunel, H. dos S. S., Malard, P. F., & Andrade, R. V. (2020). Homoeopathic Viscum album
extract inhibits the growth of osteosarcoma cells. Journal of Integrated Standardized Homoeopathy, 3, 59.
https://doi.org/10.25259/JISH_32_2020
11) Valle, A. C. V., Aguiar, L. R., Brunel, H. dos S. S., Malard, P. F., Villarroel, C. L. P., & Andrade, R. V. (2021).
Homoeopathic Viscum album (10-3) is More Cytotoxic to in vitro Culture of Human Breast Cancer Cell Line than to
Human Mesenchymal Stem Cells. International Journal of High Dilution Research – ISSN 1982-6206, 19(4), 25–34.
https://doi.org/10.51910/ijhdr.v19i4.1036
12) Yoon, T. J., Yoo, Y. C., Kang, T. B., Song, S. K., Lee, K. B., Her, E., Song, K. S., & Kim, J. B. (2003). Antitumor activity
of the Korean Mistletoe Lectin is attributed to activation of macrophages and NK cells. Archives of Pharmacal Research,
26(10), 861. https://doi.org/10.1007/BF02980033