ABSTRACT:

Because of its therapeutic promise in treating epilepsy, obesity, diabetes, and other metabolic diseases, the high-fat, low-carb ketogenic diet (KD) generates a metabolic state of ketosis with growing clinical interest. Although KD has advantages, its biochemical consequences on clinical chemistry values call for cautious review. The objective of this study is to explore and describe the effects of the ketogenic diet on important clinical chemical parameters and the employed diagnostic procedures for monitoring them. Relevant studies examining the impact of KD on biochemical indicators including blood glucose, lipid profile, liver enzymes, renal function, inflammatory markers, and ketone bodies were identified by means of relevant literature from databases including PubMed, Scopus, and ScienceDirect. Special focus was on the diagnostic instruments used in research and clinical environments. Often leading to decreased glucose and insulin levels, increased ketone bodies, changed lipid profiles (e.g., increased LDL, dropped triglycerides), and alterations in renal and hepatic enzyme levels, KD dramatically modifies metabolic indicators. Blood chemistry panels, urine for ketone detection, and point-of-care testing (POCT) for glucose and β-hydroxybutyrate define most diagnostic monitoring. Although short-term changes are typically tolerable, long-term adherence calls for consistent monitoring to avoid problems such electrolyte imbalance or ketoacidosis. In summary, the ketogenic diet clearly influences several clinical chemistry markers. Safely monitoring patients and maximizing results depend on doctors knowing these changes and using suitable diagnostic instruments. Future studies should concentrate on developing personalised monitoring rules and improving diagnosis techniques.

KEYWORDS :

Ketogenic diet, Clinical chemical parameters, Diagnostic tests.

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