The Active Ingredients and Therapeutic Effects of Cinnamon: A Review Article

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The Active Ingredients and Therapeutic Effects of Cinnamon: A Review Article

1Zainab Tawfeeq Al-Joubouri, 2Warqa,a Muhammed Shariff Al-Sheikh, 3Sahar A. A. Malik Al-Saadi, 4Karzan Omer Qader, 5Ali A. Al-fahham
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Kufa, Najaf, Iraq,
2Department of Basic Science, Faculty of Dentistry, Al-Qadisyah University, Iraq,
3Department of Biology, College of Science, Basrah University Iraq
4Department of Biology, College of Science, Sulaimani University, Iraq
5Faculty of nursing, University of Kufa, Iraq,


ABSTRACT: 

Cinnamon is used in knocking and medicine for many centuries and in different countries. Several researches about cinnamon have exhibited its curative potentials, which include: immunomodulatory, gastroprotective, antidiabetic, antilipemic, antihypertensive, antitumor, antioxidant, antifungal, antiviral, antimicrobial. Cinnamaldehyde, Eugenol and Beta-caryophyllene are the major active ingredients in cinnamon. The mode of action for the therapeutic effects indicating the anti-diabetic and antihypertensive activities of cinnamon and its chemical components have not been deeply investigated. May systematic review articles have found that the taking the extracts or having cinnamon tea have potential antidiabetic effects. Researches about the action of cinnamon on hypertension still debated. However, a number of experimental trials have found significant antihypertensive effect for cinnamon. This review cast a brief light on the active ingredients and the activity of cinnamon in the reduction of high blood pressure and hyperglycemic status.

REFERENCES :

1) Abdelrahman, I. A., Ahad, A., Raish, M., Bin Jardan, Y. A., Alam, M. A., & Al-Jenoobi, F. I. (2023). Cinnamon modulates the pharmacodynamic & pharmacokinetic of amlodipine in hypertensive rats. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 31(9), 101737.
https://doi.org/10.1016/j.jsps.2023.101737
2) Allen, R. W., Schwartzman, E., Baker, W. L., Coleman, C. I., & Phung, O. J. (2013). Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis. Annals of family medicine, 11(5), 452–459.
https://doi.org/10.1370/afm.1517
3) Amran, D.A.; Karim H. Al-Derawi, K.H and Al-Saadi, S.A. ( 2023). Phytochemical constituents of bark essential oils of Cinnamomum zeylanicum Blume and effects on liver tissue of rats. University of Thi-Qar Journal of Science. 10(2): 165-170.
4) Barceloux D. G. (2009). Cinnamon (Cinnamomum species). Disease-a-month : DM, 55(6), 327–335.
https://doi.org/10.1016/j.disamonth.2009.03.003
5) Ghavami, A., Haghighian, H. K., Roshanravan, N., Ziaei, R., Ghaedi, E., Moravejolahkami, A. R., & Askari, G. (2021). What is the Impact of Cinnamon Supplementation on Blood Pressure? A Systematic Review and Meta-Analysis. Endocrine, metabolic & immune disorders drug targets, 21(5), 956–965.
https://doi.org/10.2174/1871530320666200729143614
6) Hadi, A., Campbell, M. S., Hassani, B., Pourmasoumi, M., Salehi-Sahlabadi, A., & Hosseini, S. A. (2020). The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials. Clinical nutrition ESPEN, 36, 10–16. https://doi.org/10.1016/j.clnesp.2020.01.002
7) Hajimonfarednejad, M., Ostovar, M., Raee, M. J., Hashempur, M. H., Mayer, J. G., & Heydari, M. (2019). Cinnamon: A systematic review of adverse events. Clinical nutrition (Edinburgh, Scotland), 38(2), 594–602.
https://doi.org/10.1016/j.clnu.2018.03.013
8) Jalali, R. Mahmoodi, M. Parisa Moosavian, S. Ferns, G.A. and Sohrabi, Z. (2020) Cinnamon supplementation improves blood pressure in type 2 diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Clin Diabetol;9(4):259-266.
9) Jamali, N., Jalali, M., Saffari-Chaleshtori, J., Samare-Najaf, M., & Samareh, A. (2020). Effect of cinnamon supplementation on blood pressure and anthropometric parameters in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials. Diabetes & metabolic syndrome, 14(2), 119–125
. https://doi.org/10.1016/j.dsx.2020.01.009
10) Moridpour, A. H., Kavyani, Z., Khosravi, S., Farmani, E., Daneshvar, M., Musazadeh, V., & Faghfouri, A. H. (2024). The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Phytotherapy research : PTR, 38(1), 117–130. https://doi.org/10.1002/ptr.8026
11) Mousavi, S. M., Karimi, E., Hajishafiee, M., Milajerdi, A., Amini, M. R., & Esmaillzadeh, A. (2020). Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition, 60(18), 3144–3154.
https://doi.org/10.1080/10408398.2019.1678012
12) PubChem Beta-Caryophyllene. [(accessed on 27 August 2019)]; Available online:
https://pubchem.ncbi.nlm.nih.gov/compound/5281515
13) Shirzad, F., Morovatdar, N., Rezaee, R., Tsarouhas, K., & Abdollahi Moghadam, A. (2021). Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension. Avicenna journal of phytomedicine, 11(1), 91–100.
14) Stevens N. (2020) Cinnamon Bark Essential Oil and a Novel Essential Oil Blend as Potential Modulators of Glucose Metabolism. Ph.D. Thesis. University of Miami; Miami, FL, USA:. [(accessed on 1 December 2021)].. Available online: https://scholarship.miami.edu/esploro/outputs/doctoral/Cinnamon-Bark-Essentialoil-and-a/991031454482202976
15) Stevens, N., & Allred, K. (2022). Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations. Molecules (Basel, Switzerland), 27(3), 853. https://doi.org/10.3390/molecules27030853
16) Zhu, R., Liu, H., Liu, C., Wang, L., Ma, R., Chen, B., Li, L., Niu, J., Fu, M., Zhang, D., & Gao, S. (2017). Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety. Pharmacological research, 122, 78–89. https://doi.org/10.1016/j.phrs.2017.05.019.
17) Zhou, Q., Lei, X., Fu, S., Li, Z., Chen, Y., Long, C., Li, S., & Chen, Q. (2022). Efficacy of cinnamon supplementation on glycolipid metabolism in T2DM diabetes: A meta-analysis and systematic review. Frontiers in physiology, 13, 960580. https://doi.org/10.3389/fphys.2022.960580

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