The Biochemistry and Clinical Importance of Ribonucleic Acid (RNA): A Review Article

  • Home
  • The Biochemistry and Clinical Importance of Ribonucleic Acid (RNA): A Review Article

The Biochemistry and Clinical Importance of Ribonucleic Acid (RNA): A Review Article

1Ihab Q. Ali, 2Baidaa Rasoul Dakhil, 3Bushra A. M. Abdul Azeez, 4Ali A. Al-fahham
1Ibn Sina University for Medical and Pharmaceutical Science, Iraq,
2Thi-Qar Education directorate, Thi-Qar, Iraq,
3College of Science, University of Basrah, Iraq,
4Faculty of Nursing, University of Kufa, Iraq,



ABSTRACT:

Ribonucleic acid (RNA) is a compound that is found in almost all the cells of animals, plants, microbial, and viral particles. It is constituted from a polymer of nucleotides that contain a ribose sugar. There are many main types of RNAs, but the major types that take part in protein formation: are transfer RNA (tRNA), ribosomal RNA (rRNA), and messenger RNA (mRNA). The alteration in nucleotide sequence of RNA in viruses may be responsible for development of different diseases in living organisms. There is a huge variation in RNA viruses, such as retrovirus, rhinovirus, coronavirus, which account for many human illnesses. In this review article, we shed light on the evidence-supported information about the biochemical aspects and clinical importance of RNA.


REFERENCES :

1) Almuhayawi, M.S. (2020) Propolis as a novel antibacterial agent. Saudi J. Biol. Sci., 27, 3079–3086
2) Bankova V.S., De Castro S.L., Marcucci M.C. (2000) Propolis: Recent advances in chemistry and plant origin. Apidologie.;31:3–15. doi: 10.1051/apido:2000102
3) Debiaggi, M., Tateo, F., Pagani, L., Luini, M., & Romero, E. (1990). Effects of propolis flavonoids on virus infectivity and replication. Microbiologica, 13(3), 207–213.
4) Devequi-Nunes, D., Machado, B. A. S., Barreto, G. A., Rebouças Silva, J., da Silva, D. F., da Rocha, J. L. C., Brandão, H. N., Borges, V. M., & Umsza-Guez, M. A. (2018). Chemical characterization and biological activity of six different extracts of propolis through conventional methods and supercritical extraction. PloS one, 13(12), e0207676. https://doi.org/10.1371/journal.pone.0207676
5) Kai H., Obuchi M., Yoshida H., Watanabe W., Tsutsumi S., Park Y.K., Matsuno K., Yasukawa K., Kurokawa M. (2014) In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08) J. Funct. Foods.;8:214–223. doi: 10.1016/j.jff.2014.03.019
6) Paulino, N., Abreu, S. R., Uto, Y., Koyama, D., Nagasawa, H., Hori, H., Dirsch, V. M., Vollmar, A. M., Scremin, A., & Bretz, W. A. (2008). Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis. European journal of pharmacology, 587(1-3), 296–301. https://doi.org/10.1016/j.ejphar.2008.02.067
7) Przybyłek, I., & Karpiński, T. M. (2019). Antibacterial Properties of Propolis. Molecules (Basel, Switzerland), 24(11), 2047. https://doi.org/10.3390/molecules24112047
8) Queiroga, M. C., Laranjo, M., Andrade, N., Marques, M., Costa, A. R., & Antunes, C. M. (2023). Antimicrobial, Antibiofilm and Toxicological Assessment of Propolis. Antibiotics (Basel, Switzerland), 12(2), 347. https://doi.org/10.3390/antibiotics12020347
9) Rubin, J.E.; Ball, K.R.; Chirino-Trejo, M. (2011) Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus intermedius isolated from various animals. Can. Vet. J., 52, 153–157
10) Salatino A. (2022) Perspectives for Uses of Propolis in Therapy against Infectious Diseases. Molecules.; 27(14):4594. https://doi.org/10.3390/molecules27144594
11) Salatino, A.; Salatino, M.L.F.; Negri, G. (2021) How diverse is the chemistry and plant origin of Brazilian propolis? Apidologie, 52, 1075–1097
12) Sforcin J. M. (2016). Biological Properties and Therapeutic Applications of Propolis. Phytotherapy research : PTR, 30(6), 894–905. https://doi.org/10.1002/ptr.5605
13) Shimizu, T., Hino, A., Tsutsumi, A., Park, Y. K., Watanabe, W., & Kurokawa, M. (2008). Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. Antiviral chemistry & chemotherapy, 19(1), 7–13. https://doi.org/10.1177/095632020801900102
14) Simone-Finstrom, M., Borba, R. S., Wilson, M., & Spivak, M. (2017). Propolis Counteracts Some Threats to Honey Bee Health. Insects, 8(2), 46. https://doi.org/10.3390/insects8020046
15) Urushisaki, T., Takemura, T., Tazawa, S., Fukuoka, M., Hosokawa-Muto, J., Araki, Y., & Kuwata, K. (2011). Caffeoylquinic acids are major constituents with potent anti-influenza effects in brazilian green propolis water extract. Evidence-based complementary and alternative medicine : eCAM, 2011, 254914. https://doi.org/10.1155/2011/254914
16) Veiga, R. S., De Mendonça, S., Mendes, P. B., Paulino, N., Mimica, M. J., Lagareiro Netto, A. A., Lira, I. S., López, B. G., Negrão, V., & Marcucci, M. C. (2017). Artepillin C and phenolic compounds responsible for antimicrobial and antioxidant activity of green propolis and Baccharis dracunculifolia DC. Journal of applied microbiology, 122(4), 911–920. https://doi.org/10.1111/jam.13400
17) Yoshimasu, Y., Ikeda, T., Sakai, N., Yagi, A., Hirayama, S., Morinaga, Y., Furukawa, S., & Nakao, R. (2018). Rapid Bactericidal Action of Propolis against Porphyromonas gingivalis. Journal of dental research, 97(8), 928–936. https://doi.org/10.1177/0022034518758034
18) Zulhendri, F., Chandrasekaran, K., Kowacz, M., Ravalia, M., Kripal, K., Fearnley, J., & Perera, C. O. (2021). Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review. Foods (Basel, Switzerland), 10(6), 1360. https://doi.org/10.3390/foods10061360
19) Zullkiflee, N., Taha, H., & Usman, A. (2022). Propolis: Its Role and Efficacy in Human Health and Diseases. Molecules (Basel, Switzerland), 27(18), 6120. https://doi.org/10.3390/molecules27186120.

  • Share

Leave a Reply

Your email address will not be published. Required fields are marked *