1Sirajul Muna, 2Asmanidar
1STIKes Muhammadiyah Aceh, Indonesia (Corresponding Author)
2Department of Midwifery, Politeknik Kesehatan Meulaboh, Ministry of Health, Aceh, Indonesia
ABSTRACT
Introduction: Hypertension is a major health problem among postmenopausal women, largely attributable to the decline in estrogen levels, which results in the loss of estrogen’s cardioprotective effects and leads to increased vascular stiffness and elevated blood pressure. Although pharmacological therapy remains the primary approach for hypertension management, long-term use of antihypertensive medications is often associated with adverse effects and reduced treatment adherence. Therefore, safe and accessible non-pharmacological interventions are needed. Tomato juice, which is rich in bioactive compounds such as lycopene and potassium, has been suggested as a potential dietary intervention for blood pressure control.
Objective: This study aimed to evaluate the effectiveness of tomato juice consumption in reducing systolic and diastolic blood pressure among postmenopausal women with hypertension.
Methods: A pre-experimental study with a one-group pretest–posttest design was conducted in the service area of a primary healthcare center in Banda Aceh, Indonesia. The study involved 22 postmenopausal women with mild to moderate hypertension who were selected using purposive sampling. The intervention consisted of daily administration of 250 mL of tomato juice for four consecutive days. Blood pressure was measured before and after the intervention, and data were analyzed using the Wilcoxon Signed-Rank Test.
Results: The results demonstrated a significant reduction in mean systolic blood pressure by 12.5 mmHg, from 156.25 mmHg to 143.75 mmHg, and in mean diastolic blood pressure by 15.0 mmHg, from 98.75 mmHg to 83.75 mmHg. Statistical analysis indicated that these reductions were significant, with p-values of 0.005 for systolic blood pressure and 0.001 for diastolic blood pressure (p < 0.05).
Conclusion: Regular consumption of tomato juice for four consecutive days was effective in significantly reducing both systolic and diastolic blood pressure among postmenopausal women. This intervention may serve as a safe and practical non-pharmacological strategy for hypertension management in postmenopausal populations.
KEYWORDS
tomato juice; hypertension; menopause; blood pressure; lycopene
REFERENCES
1) L. Hoga, J. Rodolpho, B. Gonçalves, and B. Quirino, “Women’s experience of menopause: a systematic review of qualitative evidence,” JBI Database System. Rev. Implement. Rep., vol. 13, no. 8, pp. 250–337, 2015, doi: 10.11124/JBISRIR-2015-1948.
2) L. Lorefice, M. N. D’alterio, D. Firinu, G. Fenu, and E. Cocco, “Impact of Menopause in Patients with Multiple Sclerosis: Current Perspectives,” Int. J. Womens Health, vol. 15, p. 103, Jan. 2023, doi: 10.2147/IJWH.S334719.
3) B. Strelow, D. O’Laughlin, T. Anderson, J. Cyriac, J. Buzzard, and A. Klindworth, “Menopause Decoded: What’s Happening and How to Manage It,” J. Prim. Care Community Health, vol. 15, p. 21501319241307460, Jan. 2024, doi: 10.1177/21501319241307460.
4) A. Jahan-Mihan et al., “The Impact of Parental Preconception Nutrition, Body Weight, and Exercise Habits on Offspring Health Outcomes: A Narrative Review,” Nutrients 2024, Vol. 16, vol. 16, no. 24, Dec. 2024, doi: 10.3390/NU16244276.
5) V. M. Aguayo and P. Menon, “Stop stunting: Improving child feeding, women’s nutrition and household sanitation in South Asia,” Matern. Child Nutr., vol. 12, pp. 3–11, May 2016, doi: 10.1111/MCN.12283.
6) H. G. Burger, E. C. Dudley, D. M. Robertson, and L. Dennerstein, “Hormonal changes in the menopause transition,” Recent Prog. Horm. Res., vol. 57, pp. 257–275, 2002, doi: 10.1210/RP.57.1.257.
7) C. Baker and B. A. Benayoun, “Menopause Is More Than Just Loss of Fertility,” Public Policy Aging Rep., vol. 33, no. 4, p. 113, Dec. 2023, doi: 10.1093/PPAR/PRAD023.
8) K. Żmuda, M. Leszko, and K. Karasiewicz, “Perceptions and attitudes towards menopause and perceived satisfaction with life,” Prz. Menopauzalny, vol. 24, no. 1, p. 25, 2025, doi: 10.5114/PM.2025.149997.
9) A. V. Chobanian et al., “The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 report,” J. Am. Med. Assoc., vol. 289, no. 19, pp. 2560–2572, May 2003, doi: 10.1001/JAMA.289.19.2560.
10) T. W. Buford, “Hypertension and Aging,” Ageing Res. Rev., vol. 26, p. 96, Mar. 2016, doi: 10.1016/J.ARR.2016.01.007.
11) R. Lima, M. Wofford, and J. F. Reckelhoff, “Hypertension in Postmenopausal Women,” Curr. Hypertens. Rep., vol. 14, no. 3, p. 254, Jun. 2012, doi: 10.1007/S11906-012-0260-0.
12) S. Goorani, S. Zangene, and J. D. Imig, “Hypertension: A Continuing Public Healthcare Issue,” International Journal of Molecular Sciences 2025, Vol. 26, vol. 26, no. 1, Dec. 2024, doi: 10.3390/IJMS26010123.
13) R. Lima, M. Wofford, and J. F. Reckelhoff, “Hypertension in postmenopausal women,” Curr. Hypertens. Rep., vol. 14, no. 3, pp. 254–260, Jun. 2012, doi: 10.1007/S11906-012-0260-0.
14) M. Eghbali-Babadi, A. Khosravi, A. Feizi, H. Alikhasi, N. Kheirollahi, and N. Sarrafzadegan, “Prevalence of pre-hypertension and hypertension, awareness, treatment, and control of hypertension, and cardiovascular risk factors in postmenopausal women,” ARYA Atheroscler., vol. 17, no. 5, p. 1, Jan. 2021, doi: 10.22122/ARYA.V17I0.2181.
15) A. Venket Rao, “Processed tomato products as a source of dietary lycopene: bioavailability and antioxidant properties,” Can. J. Diet. Pract. Res., vol. 65, no. 4, pp. 161–165, 2004, doi: 10.3148/65.4.2004.161.
16) M. O. Shafe, N. M. Gumede, T. T. Nyakudya, and E. Chivandi, “Lycopene: A Potent Antioxidant with Multiple Health Benefits,” J. Nutr. Metab., vol. 2024, no. 1, p. 6252426, Jan. 2024, doi: 10.1155/2024/6252426.
17) A. Basu and V. Imrhan, “Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials,” Eur. J. Clin. Nutr., vol. 61, no. 3, pp. 295–303, Mar. 2007, doi: 10.1038/SJ.EJCN.1602510.
18) S. Das, H. Otani, N. Maulik, and D. K. Das, “Lycopene, tomatoes, and coronary heart disease,” Free Radic. Res., vol. 39, no. 4, pp. 449–455, Apr. 2005, doi: 10.1080/10715760500053685.
19) R. C. Greer et al., “Potassium-Enriched Salt Substitutes as a Means to Lower Blood Pressure: Benefits and Risks,” Hypertension, vol. 75, no. 2, pp. 266–274, Feb. 2020, doi: 10.1161/HYPERTENSIONAHA.119.13241.
20) E. J. Collins, C. Bowyer, A. Tsouza, and M. Chopra, “Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation,” Biology (Basel)., vol. 11, no. 2, p. 239, Feb. 2022, doi: 10.3390/BIOLOGY11020239.
21) M. R. Islam et al., “Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies,” Natural Products and Bioprospecting 2023 13:1, vol. 13, no. 1, pp. 45-, Oct. 2023, doi: 10.1007/S13659-023-00411-1.
22) M. Y. Ali et al., “Nutritional Composition and Bioactive Compounds in Tomatoes and Their Impact on Human Health and Disease: A Review,” Foods, vol. 10, no. 1, p. 45, Jan. 2020, doi: 10.3390/FOODS10010045.
23) T. Behl et al., “Pleotropic Effects of Polyphenols in Cardiovascular System,” Biomedicine & Pharmacotherapy, vol. 130, p. 110714, Oct. 2020, doi: 10.1016/J.BIOPHA.2020.110714.
24) M. Rondanelli et al., “Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid,” Nutrients 2022, Vol. 14, vol. 14, no. 1, Dec. 2021, doi: 10.3390/NU14010074.
25) S. G. Vlachovsky et al., “Ovariectomy and high salt increase blood pressure and alter sodium transport proteins in peripheral blood mononuclear cells of adult Wistar rats,” Exp. Physiol., vol. 106, no. 10, pp. 2107–2123, Oct. 2021, doi: 10.1113/EP089553.
26) A. A. Banday, Y. S. Lau, and M. F. Lokhandwala, “Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley rats,” Hypertension, vol. 51, no. 2, pp. 367–375, Feb. 2008, doi: 10.1161/HYPERTENSIONAHA.107.102111.
27) S. Sharma, K. McFann, M. Chonchol, I. H. De Boer, and J. Kendrick, “Association between Dietary Sodium and Potassium Intake with Chronic Kidney Disease in U.S. Adults: A Cross-Sectional Study,” Am. J. Nephrol., vol. 37, no. 6, p. 526, Jun. 2013, doi: 10.1159/000351178.
