ABSTRACT:
Background: It’s intriguing to learn about the various ways traditional plants can be used to treat medical issues. Many studies are being undertaken to see how traditional herbal fruits can help with a variety of medical conditions, including immunodeficiency syndrome.
Methods:
We employed network pharmacology to discover a biological link between the pharmacological effects of myrolan wood or Haritaki or Terminalia chebula, a traditional Asian medicinal fruit, and HIV pathogenesis in this study.
Results:
The scientists discovered the common pathway by blocking reverse transcriptase using interrelationship analysis.
Conclusion:
Terminalia chebula as an HIV treatment could be beneficial. More investigation into the usefulness of myrolan wood fruit in the treatment of HIV is recommended.
KEYWORDS:
HIV, myrolan wood, fruit
REFERENCES:
1) Akram M, Tahir IM, Shah SMA, Mahmood Z, Altaf A, Ahmad K, Munir N, Daniyal M, Nasir S, Mehboob H Antiviral
potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review.. Phytother
Res. 2018 May;32(5):811-822.
2. Lorenc A, Robinson N. A review of the use of complementary and alternative medicine and HIV: issues for patient care.
AIDS Patient Care STDS. 2013 Sep;27(9):503-10.
3. Nigam M, Mishra AP, Adhikari-Devkota A, Dirar AI, Hassan MM, Adhikari A, Belwal T, Devkota HP. Fruits of
Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities
Phytother Res. 2020 Oct;34(10):2518-2533.
4. Belapurkar P, Goyal P, Tiwari-Barua P. Immunomodulatory effects of triphala and its individual constituents: a review.
Indian J Pharm Sci. 2014 Nov-Dec;76(6):467-75.
5. Sriwijitalai W and Wiwanitkit V. Effect of ginseng against tuberculosis: A pathway interrelationship analysis. Biomed
Biotechnol Res J 2019;3:120-125
6. Yuan H, Ma Q, Cui H, Liu G, Zhao X, Li W and Piao G. How can synergism of Traditional Medicines Benefit from
Network Pharmacology? Molecules 2017;22(7). pii: E1135.
7. Li S and Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat
Med 2013;11:110-120.
8. Hao da C and Xiao PG. Network pharmacology: a Rosetta Stone for traditional Chinese medicine. Drug Dev Res
2014;75:299-312.
9. Yasri S and Wiwanitkit V. Protein tyrosine phosphatase, opisthorchiasis and HIV: A proteomics interrelationship. J Vector
Borne Dis 2018;55:245.
10. Wiwanitkit V. Cancer immunomics and application of ‘omics’ for cancer management. Expert Rev Clin Immunol
2007;3:807-812.
11. Baliga MS. Triphala, Ayurvedic formulation for treating and preventing cancer: a review. J Altern Complement Med .
2010 Dec;16(12):1301-8.
12. Mishra NN, Kesharwani A, Agarwal A, Polachira SK, Nair R, Gupta SK. Herbal Gel Formulation Developed for AntiHuman Immunodeficiency Virus (HIV)-1 Activity Also Inhibits In Vitro HSV-2 Infection. Viruses. 2018 Oct
24;10(11):580
13. Ahn MJ, Kim CY, Lee JS, Kim TG, Kim SH, Lee CK, Lee BB, Shin CG, Huh H, Kim J. Inhibition of HIV-1 integrase by
galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis. Planta Med. 2002
May;68(5):457-9.
14. el-Mekkawy S, Meselhy MR, Kusumoto IT, Kadota S, Hattori M, Namba T. Inhibitory effects of Egyptian folk medicines
on human immunodeficiency virus (HIV) reverse transcriptase. Chem Pharm Bull (Tokyo). 1995 Apr;43(4):641-8.
15. Hu WS, Hughes SH. HIV-1 reverse transcription. Cold Spring Harb Perspect Med. 2012 Oct 1;2(10):a006882
