Anthrax as a Zoonotic Infection: A “One Health” Perspective and Achieving Sustainable Development Goals

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Anthrax as a Zoonotic Infection: A “One Health” Perspective and Achieving Sustainable Development Goals

Ozdan Akram Ghareeb
Medical Technical Institutes Kirkuk, Northern Technical University, Iraq
ABSTRACT

Anthrax is one of the most lethal zoonotic diseases with its ability to persist in the environment for decades and its high mortality rates in humans and animals caused by Bacillus anthracis. This article reviews the pathogen’s life cycle and virulence factors such as the triple toxin complex and the capsid, which is resistant to phagocytosis, and is encoded by the plasmid pXO2 and pXO1, respectively. It also serves as an indicator of establishment and dispersion from soil reservoirs and grazing animals, human infection patterns and security implications due to its designation as a biological weapon. The results of the review confirms the importance of the two-fold approach: veterinary and environmental (annual livestock vaccination, prohibit autopsies, safe disposal of carcasses) and human medical (medical and treatment) interventions. As conclusion, this approach is directly linked to the achievement of the United Nations Sustainable Development Goals, namely Goal 3 (Good Health and Well-being), Goal 2 (Zero Hunger) and Goal 15 (Life on Land).

 

KEYWORDS 

Anthrax , zoonotic infections, Bacillus anthracis, One Health.

 

REFERENCES

1) Ghareeb OA, Sultan AI. Crimean-Congo Hemorrhagic Fever: A Re-emerging Zoonosis. An Overview of Disease and Health Research Vol. 2. 2025 Jun 2;2:37-47.
2) Bose B, Siva Kumar S. Economic burden of zoonotic and infectious diseases on livestock farmers: a narrative review. Journal of Health, Population and Nutrition. 2025;44(1):158.
3) Ghareeb OA. Hantavirus: A Zoonotic Pathogen and Its Role in Achieving Sustainable Development. International Journal of Multidisciplinary and Innovative Research. 2026; 3(7): 612-618.
4) Verma M, Maan HS, Konatam S, Verma Y, Kumar R, Chaurasia D, Dave L, Sharma S. Geographical and Ecological Drivers of Zoonotic Viral Spillover: A Review of Emerging and Re-emerging Outbreaks. Cureus. 2025 Dec 22;17(12):e99820.
5) Ullah MF. Anthropogenic influence, microbes and zoonotic diseases: Ecological imbalance, diverse impact and the One Health approach. Journal of Vector Borne Diseases. 2026 Jan 1;63(1):1-5.
6) Ghareeb OA, Ali QA. Waterborne bacterial pathogen: A global health issue for sustainable development. Disease and Health: Research Developments. 2024;2:58-69.
7) Pandey DK, Sharma R, Kumar K, Ranjan K. Transmission of antimicrobial resistance between humans, animals, and the environment. InAntimicrobial Resistance in Humans, Animals, and the Environment 2026 Jan 1 (pp. 247-264). Academic Press.
8) Bamidele TA, Odumosu BT, Kareem KO, Sarumoh BM, Musa AZ, Osuolale KA, Fowora MA, Aiyedogbon AS, Ikpo CJ, Yusuf JA, Fagbo SF. Evidence of anthrax virulence genes in Bacillus aerius and human exposure in largest abattoir in Lagos, Nigeria. One Health Outlook. 2025 Sep 26;7(1):43.
9) Pal M, Dhanze H, Regassa M, Tafesse W. An overview of anthrax: a neglected zoonosis of the tropical region. J Bacteriol Mycol Open Access. 2024;12(1):13-7.
10) Aladejana OM, Oladele JO, Oginni SA. Systematic review of anthrax, a zoonotic bacterial infection in Africa. Animal Research International. 2023 Dec 29;20(3):5143-52.
11) Ala IU, Er B, Khoo J, Chan JS, Aung KT. Global surveillance of anthrax outbreaks in domestic animals and humans: A retrospective secondary analysis of reported cases over two decades (2005–2024). One Health. 2026 Jun 7:101460.
12) Ghareeb OA, Ali QA, Ramadhan SA, Sultan AI. Concepts of one health approach and achieving sustainable development. European Journal Pharmaceutical and Medical Research. 2024;11(4):383-9.
13) Ghareeb OA. Rabies: A Neglected Tropical Zoonotic Disease; Implementation of A One Health Approach for Urgent Control. International Journal of Multidisciplinary and Innovative Research. 2026 Mar;3(3):209-215.
14) Parija SC. Bacillus. InTextbook of Microbiology and Immunology 2023 Mar : 407-418.
15) Cullimore R. Direct Evidence of a Bacterial Event. InMicrobiology of Well Biofouling 2018 May 4: 29-75.
16) Bhunia AK. Bacillus cereus and Bacillus anthracis. InFoodborne Microbial Pathogens: Mechanisms and Pathogenesis 2018 May 22 : 193-207.
17) Chateau A, Van der Verren SE, Remaut H, Fioravanti A. The Bacillus anthracis cell envelope: composition, physiological role, and clinical relevance. Microorganisms. 2020 Nov 26;8(12):1864.
18) Singh SK, Mohanty NN, Gupta V, Yogisharadhya R, Prajapati A, Shivachandra SB, Garg AP. Anthrax: An overview of the disease, toxicity and relevance of the protective antigen (PA) toxin. Indian Journal of Comparative Microbiology, Immunology and Infectious Diseases. 2024;45(1):1-9.
19) Yang NJ, Neel DV, Deng L, Heyang M, Kennedy-Curran A, Tong VS, Park JM, Chiu IM. Nociceptive sensory neurons mediate inflammation induced by bacillus anthracis edema toxin. Frontiers in immunology. 2021 Aug 3;12:642373.
20) Pauker VI, Thoma BR, Grass G, Bleichert P, Hanczaruk M, Zöller L, Zange S. Improved discrimination of Bacillus anthracis from closely related species in the Bacillus cereus sensu lato group based on matrix-assisted laser desorption ionization–time of flight mass spectrometry. Journal of Clinical Microbiology. 2018 May;56(5):10-128.
21) Rahim MF, Ahmad MZ, Naeem RF, Sohoo MU, Sindhu ZU, Tahir AH, Zafar MA. Anthrax and its impact on public health. Zoonosis, Unique Scientific Publishers, Faisalabad, Pakistan. 2023;4:502-9.
22) Barandongo ZR, Dolfi AC, Bruce SA, Rysava K, Huang YH, Joel H, Kamath PL, van Heerden H, Turner WC. The persistence of time: the lifespan of Bacillus anthracis spores in environmental reservoirs. Research in Microbiology. 2023;174(6):104029.
23) Salgado JR, Rabinovitch L, Gomes MD, Allil RC, Werneck MM, Rodrigues RB, Picão RC, Oliveira Luiz FB, Vivoni AM. Detection of Bacillus anthracis and B acillus anthracis-like spores in soil from state of Rio de Janeiro, Brazil. Memorias do Instituto Oswaldo Cruz. 2020 Nov 6;115:e200370.
24) Carlson CJ, Getz WM, Kausrud KL, Cizauskas CA, Blackburn JK, Bustos Carrillo FA, Colwell R, Easterday WR, Ganz HH, Kamath PL, Økstad OA. Spores and soil from six sides: interdisciplinarity and the environmental biology of anthrax (Bacillus anthracis). Biological Reviews. 2018 Nov;93(4):1813-31.
25) Bakhteeva I, Timofeev V. Some peculiarities of anthrax epidemiology in herbivorous and carnivorous animals. Life. 2022 Jun 10;12(6):870.
26) Alam ME, Kamal MM, Rahman M, Kabir A, Islam MS, Hassan J. Review of anthrax: A disease of farm animals. Journal of Advanced Veterinary and Animal Research. 2022 Jun 30;9(2):323.
27) Hsieh HY, Stewart GC. Does environmental replication contribute to Bacillus anthracis spore persistence and infectivity in soil?. Research in Microbiology. 2023;174(5):104052.
28) Nwinyi OC, Ajayi AT, Owolabi AT. Advancements in Bacillus anthracis Diagnostic and Treatment Techniques. InHarnessing Biotechnology Tools for Product Development: Selected Papers from the International Biotechnology Conference Exhibition and Workshop (IBCEW 2024) 2025 May 17 : 29-42.
29) Sangwan N, Gangwal A, Jain P, Langtso C, Srivastava S, Dhawan U, Baweja R, Singh Y. Anthrax: transmission, pathogenesis, prevention and treatment. Toxins. 2025;17(2):56.
30) Chowdhury S, Islam MS, Haider N, Hossain MB, Alam MA, Sharif MA, Uzzaman MS, Rahman M, Rahman M, Haque F. Risk factors associated with cutaneous anthrax outbreaks in humans in Bangladesh. Frontiers in public health. 2024 Oct 15;12:1442937.
31) Czekaj Z, Klimowicz-Bodys MD, Kaniak R, Florek M, Rypuła K. Bacillus anthracis infection in humans and animals. Med Weter. 2024 Jul 1;80:6886-2024.
32) Burroughs OS, Skaar EP. Bacillus anthracis: biological origins and impact on human history. Microbiology and Molecular Biology Reviews. 2026 Aug 25:e00274-25.
33) Huang C, Zhang H, Xiao M, Chen L, Shao Q, Su J, Li M, Zhang S, Sun H, Liu J, Huang S. Investigation and Response to the First Case of Inhalational Anthrax Caused by Inhaling Wind-Blown Dust Containing Bacillus anthracis Spores—Kaifeng City, Henan Province, China, 2026. China CDC Weekly. 2026 Aug 14;8(33):1042-6.
34) Shah K, Khan MI, Guo Y, Adnan M, Wu H. Infectious bacteria as biological warfare agents: mechanisms, epidemiological threats, and defense strategies. Frontiers in Bioengineering and Biotechnology. 2026 May 18;14:1805294.
35) Qadeer A, Azam M, Hoque MM, Abdul B. A review on nanomaterial-based biosensors technology for the detection of biological threats. Nanotechnology for Environmental Engineering. 2026 Mar;11(1):16.
36) Pradhan M, Barik M, Behera M, Nanda B, Wasif R, Lenka S, Kundu U. Threat of microbial toxins as a bioterrorism agent. InInvestigative and Predictive Forensic Microbiology 2026 Jan :281-298.
37) Burroughs OS, Skaar EP. Bacillus anthracis: biological origins and impact on human history. Microbiology and Molecular Biology Reviews. 2026 Aug 25:e00274-25.
38) Nunez CM, Benn JS, Blue-McLendon A, Chaki SP, Ficht TA, Rice-Ficht AC, Cook WE. In vitro protection and titer duration of anthrax-specific antibodies following subcutaneous vaccination of white-tailed deer (Odocoileus virginianus) with Bacillus anthracis Sterne 34F2 strain spores. The Journal of Wildlife Diseases. 2024;60(1):179-83.
39) Sarker MS, Shahid MA, Rahman MB, Nazir KN. An integrated model for anthrax-free zone development in developing countries. Journal of infection and public health. 2023 Dec 1;16:141-52.
40) Mutesi C, Migisha R, Katumba H, Ainembabazi B, Naiga HN, Mutahunga B, Ouma F, Tumwesigye A, Ilimaso F, Bulage L. Anthrax outbreak associated with the consumption and handling of carcasses of livestock that suddenly died, Kanungu District, Uganda, June–November 2024. PLOS Neglected Tropical Diseases. 2026;20 (7) : e0013727.
41) Subedi D, Pantha S, Jyoti S, Gautam B, Kaphle K, Yadav RK, Ghimire S, Dhakal S. Anthrax in humans, animals, and the environment and the one health strategies for Anthrax control. Pathogens. 2024 Sep 7;13(9):773.
42) Qiao Z, Wang S, Shi Y, Zhu L, Zhang W, Gao J. Human anthrax vaccines: Current status and future prospects. Human Vaccines & Immunotherapeutics. 2025 31;21(1):2595774.
43) Drobic B, Akintunde G, Kim J, Mirceta M, Beach M, Komlenovic V. Effect of Co-administration of the anthrax vaccine adsorbed, adjuvanted with ciprofloxacin or doxycycline on antibiotic pharmacokinetics and the vaccine immunogenicity: A phase 2 drug-vaccine interaction study. Vaccine. 2026 Feb 15;73:128135.
44) Hossain MB, Dee M, Springer C, Butler R. Risk Factors for Human Anthrax Infection on a Global Scale: Understanding and Quantifying Outbreak-Related Exposure Behaviors Within Socio-Demographic and Cultural Contexts. Zoonotic Diseases. 2026 11;6(1):6.
45) Ali QA, Ghareeb OA. Wastewater Management and Its Role in Achieving the Various Goals of Sustainable Development: A Review. Emerging Issues in Environment, Geography and Earth Science, 2024; 7: 135–149.
46) Mumba C, Phiri D, Kabbudula E, Gondwe L, Mebelo N, Simweene G, Hankolwe MN, Besa K, Sichone SS, Kayula M, Geoffrey M. Exploring community knowledge, perceptions, and the impacts of anthrax among farming communities living in game management areas in Zambia: A qualitative study using a hybrid approach. PLOS Neglected Tropical Diseases. 2025 May 8;19(5):e0012852.
47) Waheed MT, Malik MS, Saba K, Younus I, Ahmad N, Mirza B, Lössl AG. Plant-based Vaccines against Livestock Diseases: Way to Achieve Several Sustainable Development Goals. InApplications in Plant Biotechnology 2022 Dec 23 : 204-238.
48) Marrana M. Epidemiology of disease through the interactions between humans, domestic animals, and wildlife. InOne health 2022 Jan : 73-111.

 

Cite this article

Ghareeb, O. A. (2026). Anthrax as a Zoonotic Infection: A “One Health” Perspective and Achieving Sustainable Development Goals. INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH, 5(9), 910-918. https://doi.org/10.58806/ijhmr.2026.v5i9n08

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